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Pharmacotherapy of metabolic syndrome and nutrition
Nesvadbová, Eliška ; Matoulek, Martin (advisor) ; Bartošová, Olga (referee)
Introduction: Metabolic syndrome is considered a proatherogenic, proinflammatory and prothrombogenic condition, high-risk especially in terms of atherosclerotic cardiovascular diseases. Presence of metabolic syndrome is connected with plenty of other disorders. The prevalence in adult European population is 20-30 % and it's expected to rise in the future. In metabolic syndrome treatment and prevention non-pharmacological therapy including regular physical activity, keeping of optimal weight and rational diet has essential importance. Principle of pharmacotherapy is a choice of optimal antidiabetics, hypolipidemics, antihypertensives and eventually anti-obesity drugs. For long-term compensation of metabolic syndrome, pharmacotherapy of associated diseases is also essential. Some medicaments can have negative effects on glycemia, blood lipids, body weight or blood pressure, so the choice of medication isn't always easy. Objectives: The main objective of this thesis includes the description of pharmacotherapy of metabolic syndrome and associated diseases in questioned patients. The research is focused on medicaments and combinations of medicaments with positive effect on metabolic syndrome components, and also on substances potentially inappropriate for patients with metabolic syndrome. The secondary...
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